IBDome explorer

The IBDome-explorer is a comprehensive resource developed as part of the TRR241 research initiative. It integrates large-scale omic datasets from patients with Inflammatory Bowel Diseases (IBD), such as Crohn’s disease and ulcerative colitis, along with detailed clinical information. TRR241, funded by the German Research Foundation (DFG), brings together leading research institutions from Erlangen, Berlin, Kiel, and Innsbruck to enhance our understanding of the molecular and cellular mechanisms behind IBD. The database contains a wide array of data, including endoscopy-, histopathology- and stool-scores, protein abundances from the serum, whole exome- and RNA-sequencing data along with high-resolution H&E images. By combining these diverse data types, IBDome offers a unique platform for researchers to explore disease mechanisms and foster advancements in IBD diagnosis and treatment strategies.

© 2024 TRR241. All rights reserved.

Data Overview

Samples and clinical variables available in the IBDome database.

Samples by sample type and tissue

Samples by sample type and disease

Samples by sample type and study center

Samples by sample type and sex

Subjects and available clinical variables

Note that not all clinical variables are available for all subjects

© 2024 TRR241. All rights reserved.

Gene expression

select samples
disease
Sex
tissue
Inflammation Status
Sampling procedure
Filter for Crohn's disease samples only
Localization L1-L3
L4 modifier
disease course B1-B3
p modifier
Filter for ulcerative colitis samples only
Localization E1-E3
select variables
Select genes
plot by this categorical variable
results
Statistics
  • Errorbars denote the 95% confidence interval of the mean
  • The p-values have been calculated using a simple Wilcoxon-Mann-Whitney test which does not take into account potential confounding factors.
  • P-values are not adjusted for multiple testing.
plot data meta
© 2024 TRR241. All rights reserved.

Correlation

select samples
disease
Sex
tissue
Inflammation Status
Sampling procedure
Filter for Crohn's disease samples only
Localization L1-L3
L4 modifier
disease course B1-B3
p modifier
Filter for ulcerative colitis samples only
Localization E1-E3
select variables
data type
data type
vs
results
Please note
  • Correlation is indicated as Pearson's r.
  • Each point represents a patient.
  • Multiple samples or clinical records (e.g. different timepoints) for a single patient are aggregated by median.
  • The trend-line has been fitted using a linear model.
  • The shaded area denotes the 95% confidence interval of the slope of the linear model.
  • Protein abundance data are represented as normalzed protein expression (NPX) values, Olink Proteomics arbitrary unit on log2 scale
plot data meta
© 2024 TRR241. All rights reserved.

IBDome Data Downloads

Download the latest data related to the IBDome project, transcriptomic and proteomic data with the acompaning meta data

IBDome version 1.0.0

Archive

Download the legacy DB archives from former IBDome app versions

© 2024 TRR241. All rights reserved.

Changelog

v1.0.0

  • Major update of appearance and redesign of layout
  • Added legal pages, imprint, privacy policy and accessibility statement
  • Adding logos and links to partner institutions

v0.6.4

  • Added updated database including inflammation status
  • Added inflammation status and sampling procedure as selectors to sample selection
  • Added inflammation status and sampling procedure as categorical variable in genexpression plotting

v0.6.3

  • Bug fixes

v0.6.2

  • Updated meta data and data download function

v0.6.1

  • Changed data handling for RNAseq data to improve performance

v0.6.0

  • Add updated database
  • Add data and meta data download
  • Add protein abundance (olink) data to correlation
  • Add sex to sample selection

v0.5.0

  • Remove page with sample overview

v0.4.1

  • Updated database version. Fixed an issue with missing histology scores for UC samples.

v0.4.0

User-facing

  • Excluded 16 RNA-seq samples with a potentially misannotated tissue, or exceptionally high blood content.
  • Add changelog.

Internal

  • Make configuration more flexible.
© 2024 TRR241. All rights reserved.

Imprint

Owner

Institute of Bioinformatics, Biocenter, Medical University of Innsbruck
Innrain 80, 6020 Innsbruck, Austria, http://icbi.at
Zlatko Trajanoski (Head), email: icbi@i-med.ac.at, Tel: +43-512-9003-71400

Content

Institute of Bioinformatics, Biocenter, Medical University of Innsbruck
Innrain 80, 6020 Innsbruck, Austria, http://icbi.at
TRR241 (Content), email:icbi@i-med.ac.at, Tel: +43-512-9003-71400
Raphael Gronauer (Developer), email: raphael.gronauer@i-med.ac.at

Liability

The text provided on these websites has been reviewed with great care. However, we cannot guarantee the accuracy, completeness or validity of the information provided. Therefore the Institute of Bioinformatics, Medical University of Innsbruck accepts no liability for the contents provided. Links to other websites have been carefully selected. However, the Institute of Bioinformatics, Medical University of Innsbruck is not responsible for contents on any other websites. The software is provided ‘as is’ without warranty of any kind, either express or implied, including, but not limited to, the warranties of merchantability, fitness for a particular purpose, and non-infringement. In no event shall the authors or copyright holders be liable for any claims, damages, or other liability, whether in contract, tort, or otherwise, arising out of the software or the use or other dealings in the software.

Licence

Copyright (c) 2024 Institute of Bioinformatics, Medical University of Innsbruck

This webside is provided under CC BY licence.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
CC BY includes the following elements:
BY: credit must be given to the creator.

Disclosure according to §25 Media Act

Media owner:
Institute of Bioinformatics, Biocenter, Medical University of Innsbruck
Medical University of Innsbruck
Innrain 80/82
A - 6020 Innsbruck

Data Protection Officer of the Medical University of Innsbruck:
Mr Georg Fellner LL.M. Lawyer at bkp (Brauneis Klauser Prändl Rechtsanwälte GmbH), Vienna
E-mail: datenschutzbeauftragter@i-med.ac.at

To the privacy policy.
To the declaration of barrier-free access to the website.

Funding

This work was funded by the Austrian Science Fund (FWF) [grant nr. I3978], the Deutsche Forschungsgemeinschaft (DFG) [grant nr. 375876048]

© 2024 TRR241. All rights reserved.

Documentation

RNAseq-analysis

...

© 2024 TRR241. All rights reserved.

Declaration on accessibility

General information

We endeavour to make our websites accessible in accordance with The Web Accessibility Directive (WAD) as amended to implement Directive (EU) 2016/2102 of the European Parliament and of the Council of 26 October 2016 on the accessibility of the websites and mobile applications of public sector bodies (OJ L 327, 2.12.2016, p. 1).

This accessibility statement applies to the website https://www.ibdome.org'

Status of compliance with the requirements:

This website is partially compliant with conformance level AA of the Web Content Accessibility Guidelines Web - WCAG 2.1 or with the applicable European Standard EN 301 549 V2.1.2 (2018-08) due to the following incompatibilities and exceptions.


Non-accessible content:

Images and photos:
Decorative images and photos do not have captions or alternative
text and are therefore not accessible for screen reader users*.

Interactive plots and diagrams:
Plots and diagrams do not have alternative texts or text-based
descriptions, making them difficult to use by screen readers or text-based systems.

Input screens:
Due to technical limitations, the input masks are not optimally
adaptable for use with a keyboard or screen reader.

Drop-down menus:
Extensive drop-down menus impair usability, especially for users
with motor impairments or when navigating with a screen reader.

We are working to identify these barriers and develop
solutions to make it more accessible for all users.

Our long-term goal is to make interaction with the tool as barrier-free as possible.
If you have any feedback or specific suggestions for improvement, please do not hesitate to contact us.

Despite our best efforts, users may experience problems. Please contact us if you notice a problem that is not listed.


Creation of this accessibility statement

This statement was created on 25.11.2024.

© 2024 TRR241. All rights reserved.

Citation

To cite the IBDome Explorer in your work, please use the following reference:
IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases C. Plattner, G. Sturm, A.A. Kühl, R. Atreya, S. Carollo et. al bioRxiv 2025, doi: https://doi.org/10.1101/2025.03.26.645544

© 2024 TRR241. All rights reserved.

Privacy policy

General information

This statement describes how the ICBI of the Medical University of Innsbruck processes your data in connection with this website. When handling personal data, we observe all data protection regulations as amended from time to time. The ICBI of the Medical University of Innsbruck undertakes to comply with the legal data protection regulations, but is not responsible if third parties - despite all security measures - nevertheless succeed in gaining access to data and information in an unlawful manner. Please note that complete protection of data against access by unauthorised third parties is not possible. We take all necessary and proportionate technical and organisational measures in accordance with Art. 32 GDPR to ensure an appropriate level of protection. The measures are regularly reviewed and updated and adapted to the current state of the art. Despite these measures, we cannot guarantee that individual systems and services will always be available without restriction or interruption.

Purpose of the processing of personal data

Your personal data will only be processed for the following purposes within the meaning of Art. 6 (1) GDPR:
To make the website available
To respond to enquiries
To be able to create usage statistics
For order processing
Furthermore, your personal data will only be stored for as long as is necessary to fulfil the respective purpose or within the scope of statutory retention periods. If consent is required for the lawful processing of your data, we will obtain your express consent prior to processing.

Data processed by this website:

Browser type, version and language setting
Model designation of the end device and a generic device identifier
Operating system used
Website from which the user visits the website of the Medical University of Innsbruck (referrer URL)
Website visited by the user
Date and time of access
Anonymised IP address of the user's computer

Changes to the privacy policy

We reserve the right to amend the data protection declaration in order to adapt it to changed legal situations or in the event of changes to the service and data processing. Users are therefore requested to inform themselves regularly about its content. We would like to point out that the use of this website is subject to copyright, name and trademark rights as well as other third-party rights. You undertake to refrain from misusing the entire content (in particular images, videos, fonts and trademarks). You may choose to prevent this website from aggregating and analysing the actions you take here. Doing so will protect your privacy, but will also prevent the owner from learning from your actions and creating a better experience for you and other users.

© 2024 TRR241. All rights reserved.

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